Multivariate models for prediction of human skin sensitization hazard
نویسندگان
چکیده
منابع مشابه
Multivariate models for prediction of human skin sensitization hazard.
One of the Interagency Coordinating Committee on the Validation of Alternative Method's (ICCVAM) top priorities is the development and evaluation of non-animal approaches to identify potential skin sensitizers. The complexity of biological events necessary to produce skin sensitization suggests that no single alternative method will replace the currently accepted animal tests. ICCVAM is evaluat...
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Skin sensitization is a major environmental and occupational health hazard. Although many chemicals have been evaluated in humans, there have been no efforts to model these data to date. We have compiled, curated, analyzed, and compared the available human and LLNA data. Using these data, we have developed reliable computational models and applied them for virtual screening of chemical librarie...
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ژورنال
عنوان ژورنال: Journal of Applied Toxicology
سال: 2016
ISSN: 0260-437X
DOI: 10.1002/jat.3366